University magna graecia of catanzaro8/13/2023 ![]() ![]() Inhibition of MBTPS1 activity decreased SREBP levels and cell proliferation in CRC-derived cell lines, while CRISPR/Cas9 KO of the MBTPS1 gene resulted in severely attenuated proliferation and downregulation of several energy metabolism pathways. The study found that membrane-bound transcription factor protease 1 (MBTPS1) is critical for the proliferation of CRC cells. investigated the role of sterol regulatory element-binding proteins (SREBPs) in CRC proliferation. ![]() In a second study, Hartal-Banishay et al. These results suggest specific metabolic adaptations for invasive cancer cells, which could serve as potential therapeutic targets. The study also found that CD36 was associated with lung metastatic tropism of CRC cells, validating the in vivo relevance of the findings. The study identified several altered lipid metabolism-related targets, including LDLR, CD36, FABP4, SCD, AGPAT1, and FASN, which were associated with the prognosis of CRC patients. ![]() investigated the metabolic and functional differences between two CRC cell lines with different metastatic organotropisms. In this Editorial, two recent studies shed light on the metabolic pathways involved in CRC and the potential therapeutic targets that may emerge from this research. Metabolic reprogramming has been implicated in CRC progression and metastasis. The major strength of this work was the use of multiple samples that allowed the identification of a subset of putative metabolic biomarkers recognizable by using minimally invasive procedures.Ĭolorectal cancer (CRC) is a prevalent malignancy worldwide and metastasis to the liver and lung is common. Here the authors integrate omics approaches to profile multiple samples of endometrial tissues disclosing that amino acid and nucleotide metabolism have a crucial role in endometrial cancer (EC). On cancer heterogeneity, is also focused the paper of Yi et al. In this scenario, being metabolic cross-talk a driver of invasion, resistance to chemotherapy and malignancies grade, it might represent a strategic target to implement personalized cancer treatments. The authors propose that the co-culture of cancer cells and CAFs might represent a smart model to investigate “real-time” the metabolic oscillations at the single-cell level unveiling the metabolic heterogeneities that surround cell symbiosis. In this perspective, the article of Amemiya and Yamaguchi aims to address the notion of a metabolic symbiosis between cancer and tumor microenvironment. Cancer is a dynamic disease and therefore tumor microenvironment results in heterogeneous cells population characterized by peculiar molecular signatures including those involving metabolism. The study of cancer metabolism has the potential to transform cancer treatment and improve patient outcomes.ĭuring carcinogenesis, cells undergo dramatic metabolic rewiring, acquiring the ability to survive in hard condition. The collection presents cutting-edge research conducted by future leaders of the discipline, with real-world applications to pressing challenges in cancer research. By understanding these processes, researchers can develop innovative strategies for diagnosing and treating cancer ( 2). This editorial collection focuses on early-career researchers who have already established themselves as internationally recognized experts in Cancer Metabolism, a rapidly growing area of research that studies metabolic changes in cancer cells ( 1). Recognizing and supporting the next generation of leaders in oncology is crucial for ensuring that we continue to drive innovation and make progress in the fight against cancer.
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